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Anti-Aging & Prevention

Anti-Aging with Spermidine and Resveratrol – The Perfect Combination for a Long Life

Spermidine and resveratrol activate autophagy – your cells' internal cleaning program. Learn how the two work synergistically and in which foods and supplements they are found.

Published on Approx. 6-minute read By Carina Manfredo-Comisso
Anti-aging with spermidine and resveratrol – the perfect combination for a long life
Spermidine and resveratrol together crank up autophagy – the cells' recycling program.

Researchers around the world are uncovering the potential of spermidine. It can have positive effects on various cells in the body and plays an essential role in metabolism, cell functions and overall health. On a molecular level, spermidine's most important effect is through autophagy – the cell's internal cleaning program. This makes it appear as a promising all-round anti-aging agent. Resveratrol also triggers the cellular recycling process, but in a different way. Combined, the two work together like interlocking gears and can boost autophagy even more effectively.

Autophagy – the Cells' Self-Cleaning Process

What is autophagy?

Autophagy is a vital process in which old, damaged or unnecessary cell components are broken down and recycled. It maintains the balance between degradation and renewal, can slow down ageing, protects against infections and may help prevent diseases.

This process occurs naturally, but can be influenced by lifestyle and certain active substances – this is where spermidine and resveratrol come into play.

A Special Team – Spermidine and Resveratrol

Both substances pursue the same goal – activating autophagy – but use different mechanisms:

Resveratrol

Activates deacetylases

Resveratrol activates deacetylases (sirtuins) and thereby starts the cellular self-cleaning.

Spermidine

Inhibits acetylases

Spermidine inhibits acetylases that would otherwise block the process – an ideal complement to resveratrol.

A research team at the Université Paris-Sud found that both substances work synergistically and reinforce each other. Together they unfold a potentiated effect on autophagy – in keeping with the motto:

Spermidine and resveratrol: together we are strong!

Foods with Spermidine and Resveratrol

Rich in spermidine

Spermidine sources

  • wheat germ and wholegrain products
  • pumpkin seeds
  • mature cheese (e.g. cheddar)
  • mushrooms
  • soy products
  • legumes
Rich in resveratrol

Resveratrol sources

  • grapes and red wine
  • raspberries, mulberries, plums
  • peanuts
  • Japanese knotweed

The amounts in foods, however, are small. Effective doses are difficult to reach through diet alone. Supplements therefore offer the possibility of taking in higher amounts in a targeted way.

Pay Attention to Quality in Supplements

Both spermidine and resveratrol are now available as supplements. Look for:

  • exact information on the content per capsule or tablet
  • high purity and tested quality

Important

Supplements do not replace a varied diet. A balanced diet and a healthy lifestyle are the basis for long-term health.

Green Health SPERMIDINE CELL PROTECT capsules from PANACEO – vegan, with vitamin C and B2
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Green Health SPERMIDINE CELL PROTECT capsules

Vegan food supplement with spermidine as well as vitamin C and B2, which contribute to protecting the cells from oxidative stress.

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Portrait of Carina Manfredo-Comisso

Carina Manfredo-Comisso

Author at PANACEO – writing about anti-aging, prevention and a healthy lifestyle.

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Note: This article is for general information only and is not a substitute for medical advice. Green Health SPERMIDINE CELL PROTECT is a food supplement and not a substitute for a balanced diet and healthy lifestyle. For health-related questions, please consult your doctor.

Frequently asked questions

Questions About Spermidine & Resveratrol

Autophagy is the cells' internal cleaning program: old, damaged or unnecessary cell components are broken down and recycled. The process maintains the balance between degradation and renewal and can slow down the ageing process.

Both activate autophagy through different routes: resveratrol activates deacetylases, spermidine inhibits acetylases. A research team at the Université Paris-Sud found that they work synergistically and reinforce each other.

Especially in wheat germ and wholegrain products, pumpkin seeds, mature cheese (e.g. cheddar), mushrooms, soy products and legumes. The amounts, however, are small – effective doses are hard to reach through diet alone.

No. Supplements do not replace a varied diet. A balanced diet and a healthy lifestyle are the basis for long-term health; supplements can complement it in a targeted way.

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